Science
Spinal Cord Injury
Spinal cord injury is a devastating neurological disorder caused by damage to the spinal cord. It affects people’s lives through loss of sensation and motor paralysis below the level of the injury. Functional recovery is often hindered by very limited capacity of the spinal cord and brain to regrow injured nerve fiber tracts and form new connections and circuits. No therapy that effectively enhances regeneration and repair of the injured spinal cord is currently available.
Therapeutic Approach
NovaGo develops human therapeutic antibodies to enhance nerve growth and regeneration by blocking the growth inhibitory membrane protein Nogo-A. This blockade of Nogo-A function stimulates the regenerative growth of nerve fibers and leads to the establishment of novel functional connections following traumatic injury.
NovaGo’s therapeutic antibody candidates have been discovered through the high-throughput analysis of human immune repertoires. Lead candidates were selected in a collaboration with Neurimmune AG that enhance nerve repair and functional recovery in preclinical models. Phase 1b clinical trials are expected to start in 2024.